Spinach Pyruvate Kinase Isoforms

Hypoxic regulation and selective silencing of pyruvate kinase isoforms

Prevalence of Pyruvate Kinase Deficiency among the Newborns (Shiraz-Iran)

Background: The frequency of pyruvate kinase (PK) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in Shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. The purpose of this study is to obtain data on the frequency and spectrum of gene mutation of PK in newborns, from Shiraz and surrounding areas. Materials and Methods...

Tissue-specific distribution of pyruvate kinase isoforms improve the physiological plasticity of Northern krill, Meganyctiphanes norvegica

The Northern krill, Meganyctiphanes norvegica (Crustacea, Euphausiacea) is widely distributed in the northern and northeastern parts of the Atlantic Ocean where it faces rapid variations in water temperatures and food. We studied the physiological potential of krill to compensate for environmentally induced metabolic changes. Two isoforms of the glycolytic key enzyme pyruvate kinase (PKI and PK...

Oleanolic Acid Suppresses Aerobic Glycolysis in Cancer Cells by Switching Pyruvate Kinase Type M Isoforms

Warburg effect, one of the hallmarks for cancer cells, is characterized by metabolic switch from mitochondrial oxidative phosphorylation to aerobic glycolysis. In recent years, increased expression level of pyruvate kinase M2 (PKM2) has been found to be the culprit of enhanced aerobic glycolysis in cancer cells. However, there is no agent inhibiting aerobic glycolysis by targeting PKM2. In this...

Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms

The Warburg effect is a well-known feature of cancer cells. However, its' functional significance hasn't been elucidated yet. Pyruvate kinase muscle (PKM), which is a rate-limiting glycolytic enzyme, has 2 isoforms, PKM1 and PKM2. It has been reported that PKM2 is a tumor-specific isoform and promotes the Warburg effect. Also, it has been thought that tumor cells switch their PKM isoform from P...